| 8/27/2021 | Callisburg | Bulldog Stadium, Howe, TX | 21-35 L |
| 9/10/2021 | at Sanger | Indian Stadium, Sanger, TX | 24-61 L |
| 9/16/2021 | Weatherford Christian School | Bulldog Stadium, Howe, TX | 20-27 L |
| 9/24/2021 | Pottsboro | Bulldog Stadium, Howe, TX | 14-59 L |
| 10/1/2021 | at Winnsboro | Red Raider Stadium, Winnsboro, TX | 17-70 L |
| 10/8/2021 | at Emory Rains | Wildcat Stadium, Rains, TX | 38-49 L |
| 10/15/2021 | Commerce (homecoming) | Bulldog Stadium, Howe, TX | 21-31 L |
| 10/22/2021 | at Mineola | Meredith Memorial Stadium, Mineola, TX | 0-50 L |
| 10/29/2021 | Bonham | Bulldog Stadium, Howe, TX | 27-60 L |
| 11/5/2021 | at Mt. Vernon | Don Meredith Stadium, Mount Vernon, TX | 6-56 L |
